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Showing 1–2 of 2 results
Advanced filters: Author: "Marc Foretz" Clear advanced filters

  • The liver is an important regulator of glucose homeostasis. Here, the authors provide insight into the molecular signalling pathways controlling hepatic gluconeogenesis by showing that SIK protein kinases suppress gluconeogenesis, and that glucagon—but not insulin—regulates phosphorylation of SIK2.

    • Kashyap Patel
    • Marc Foretz
    • Kei Sakamoto
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-16

  • Metformin is currently the first-line treatment option for patients with type 2 diabetes mellitus, yet its mechanism of action remains uncertain. A new study reveals the important role for the activation of a duodenal AMPK-dependent neuronal pathway in the acute antihyperglycaemic effect of metformin and the inhibition of hepatic glucose production.

    • Marc Foretz
    • Benoit Viollet
    News & Views
    Nature Reviews Endocrinology
    Volume: 11, P: 390-392