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Showing 1–5 of 5 results
Advanced filters: Author: "Marco Gerlinger" Clear advanced filters
  • Analysis of exome sequencing data from 42 baseline and progression biopsies from cetuximab-treated colorectal cancers reveals limited adaptive mutagenesis but shows a chemotherapy-induced mutational signature that is the main contributor of specific driver mutations that are enriched at acquired resistance.

    • Andrew Woolston
    • Louise J. Barber
    • Marco Gerlinger
    Research
    Nature Ecology & Evolution
    Volume: 5, P: 1024-1032
  • Cancer evolution is central to poor outcomes of cancer therapies, enabling tumour progression and the acquisition of drug resistance. Joint efforts of evolutionary biologists, oncologists and cancer researchers are necessary to understand the principles of cancer evolution and to derive therapeutic strategies that can control it.

    • Katharina von Loga
    • Marco Gerlinger
    Comments & Opinion
    Nature Ecology & Evolution
    Volume: 1, P: 1051-1052
  • Based on a consensus conference of experts in the evolution and ecology of cancer, this article proposes a framework for classifying tumours that includes four evolutionary and ecological processes: neoplastic cell diversity and changes over time in that diversity, hazards to cell survival and available resources.

    • Carlo C. Maley
    • Athena Aktipis
    • Darryl Shibata
    ReviewsOpen Access
    Nature Reviews Cancer
    Volume: 17, P: 605-619