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Showing 1–2 of 2 results
Advanced filters: Author: "Maria Jasin" Clear advanced filters

  • Homologous recombination maintains genome stability in mammalian mitotic cells through precise repair of DNA double-strand breaks and other lesions that occur during normal cellular metabolism and through exogenous insults. Deficiencies in genes that encode proteins involved in homologous recombination are associated with developmental abnormalities and tumorigenesis.

    • Mary Ellen Moynahan
    • Maria Jasin
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 11, P: 196-207

  • Genetic exchanges between homologous chromosomes are essential for producing haploid gametes and increase genetic diversity. Recent advances have provided insights into the mechanisms that specify recombination hot spots and the regulation of the exchange of genetic material between mammalian chromosomes.

    • Frédéric Baudat
    • Yukiko Imai
    • Bernard de Massy
    Reviews
    Nature Reviews Genetics
    Volume: 14, P: 794-806