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Showing 1–5 of 5 results
Advanced filters: Author: "Maria Ciofani" Clear advanced filters

  • AP-1 family transcription factors regulate CD4+ T helper cell differentiation. Here the authors show that the AP-1 member JunB is a nonredundant regulator of transcriptional programs that support Th17 cell identity and restrain alternative Th1 and Treg cell fates in inflammatory contexts of acute fungal infection and chronic autoimmunity.

    • Tiffany M. Carr
    • Joshua D. Wheaton
    • Maria Ciofani
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-18

  • γδ T cells are critical contributors to tissue homeostasis. Recent research identifies an unexpected role for γδ T cell–derived IL-17F in promoting sympathetic innervation and tissue thermogenesis through the induction of the cytokine TGF-β in adipose cells.

    • Maria Ciofani
    News & Views
    Nature Immunology
    Volume: 21, P: 367-368

  • What factors determine the development of γδ versus αβ T lineage cells from common thymocyte progenitor cells? Here, the authors discuss the two prevailing models for γδ versus αβ T cell development and discuss recent evidence that supports a T cell receptor signal strength model for γδ T cell lineage specification.

    • Maria Ciofani
    • Juan Carlos Zúñiga-Pflücker
    Reviews
    Nature Reviews Immunology
    Volume: 10, P: 657-663