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Showing 1–2 of 2 results
Advanced filters: Author: "Marie Noelle Simon" Clear advanced filters

  • The Nuclear Pore Complex has been linked to DNA damage processing. Here the authors reveal that the Nup1 C-terminus is critical for the relocalization of eroded telomeres to nuclear pores and that modification of Nup1 promotes sister chromatid recombination and unleashes a new telomere maintenance mechanism.

    • Paula Aguilera
    • Jenna Whalen
    • Vincent Géli
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • The enzymes Sae2 and Sgs1 regulate telomere maintenance in yeast cells that are telomerase-positive or -negative, but how they do this is unclear. Here the authors show that Sae2 and Sgs1 facilitate telomere replication in telomerase-positive cells, but generate single-stranded DNA at eroded telomeres in telomerase-negative cells.

    • Julien Hardy
    • Dmitri Churikov
    • Marie-Noëlle Simon
    Research
    Nature Communications
    Volume: 5, P: 1-13