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Showing 1–2 of 2 results
Advanced filters: Author: "Mario Delmar" Clear advanced filters

  • It is believed that mutations in desmosomal adhesion complex protein plakophilin 2 (PKP2) cause arrhythmia due to loss of cell-cell communication. Here the authors show that PKP2 controls the expression of proteins involved in calcium cycling in adult mouse hearts, and that lack of PKP2 can cause arrhythmia in a structurally normal heart.

    • Marina Cerrone
    • Jerome Montnach
    • Mario Delmar
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16

  • In myelinated fibres conduction and adhesion proteins aggregate at discrete foci, but it is unclear if this organization is present in other excitable cells. Using nanoscale visualization and in silico techniques, the authors show that adhesion/excitability nodes exist at the intercalated discs of adult cardiac muscle.

    • Alejandra Leo-Macias
    • Esperanza Agullo-Pascual
    • Mario Delmar
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12