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Showing 1–2 of 2 results
Advanced filters: Author: "Marisa S Bartolomei" Clear advanced filters
  • Topoisomerase enzymes facilitate gene transcription by resolving DNA tangles. Malfunction of these enzymes seems to compromise the expression of very long genes, potentially mediating neurodevelopmental disorders. See Article p.58

    • Robert N. Plasschaert
    • Marisa S. Bartolomei
    News & Views
    Nature
    Volume: 501, P: 36-37
  • The linked maternally expressed H19 and paternally expressed Igf2 genes use a CTCF-dependent DNA methylation–sensitive insulator to govern their allele-specific imprinting patterns. Contrary to expectations, a new study shows that the noncoding H19 RNA has a marsupial ortholog and that key features of the locus are similar, indicating that the imprinting regulation of this locus is conserved among therian mammals.

    • Marisa S Bartolomei
    • Sebastien Vigneau
    • Michael J O'Neill
    News & Views
    Nature Genetics
    Volume: 40, P: 932-933