Peroxisome proliferator-activated receptor α (PPARα) activation attenuates or inhibits several mediators of vascular damage, which indicates that PPARα could potentially be targeted by therapies to prevent microvascular disease in patients with diabetes. This Review focuses on the role of PPARα activation in diabetic microvascular disease and highlights the available experimental and clinical evidence from studies of PPARα agonists.
- Anne Hiukka
- Marianna Maranghi
- Marja-Riitta Taskinen