The human ether-a-go-go–related gene (hERG) channel regulates the heartbeat rhythm. The transition from the open to the inactivated state of human K+ channel ERG is analyzed by phi-value analysis, revealing a complex rearrangement of all domains (extracellular, transmembrane and cytoplasmic). The work thus reveals the sequence of conformational changes underlying selectivity filter gating, and may be relevant for other K+ channels.
- David T Wang
- Adam P Hill
- Jamie I Vandenberg
