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Showing 1–10 of 10 results
Advanced filters: Author: "Mark Davis" Clear advanced filters

  • The detection of multiple and often rare T cell specificities is crucial for understanding and therapeutically manipulating T cell responses. In this Perspective article, Daviset al. summarize the latest advances in peptide–MHC multimer technology that have rendered peptide–MHC multimers a valuable tool in both basic and clinical T cell research.

    • Mark M. Davis
    • John D. Altman
    • Evan W. Newell
    Reviews
    Nature Reviews Immunology
    Volume: 11, P: 551-558

  • Multiplexed assay technologies at the gene, protein, and cellular levels have enabled the identification of 'actionable biomarkers' that can inform clinical practice. Powerful new methods, including mass cytometry and protein arrays, are reviewed.

    • Holden T. Maecker
    • Tamsin M. Lindstrom
    • C. Garrison Fathman
    Reviews
    Nature Reviews Rheumatology
    Volume: 8, P: 317-328

  • Forkhead box O (FOXO) transcription factors have many diverse physiological functions and regulate gene-expression programmes that are involved in immunity, metabolism and oncogenesis. This Review discusses how FOXO proteins integrate different environmental signals in order to regulate T cell differentiation and functions in a context-dependent manner.

    • Stephen M. Hedrick
    • Rodrigo Hess Michelini
    • Erica L. Stone
    Reviews
    Nature Reviews Immunology
    Volume: 12, P: 649-661

  • Understanding the molecular events that orchestrate the formation of high-affinity memory B cells will help to improve vaccination strategies. In this Review article, McHeyzer-Williams and colleagues discuss the cellular and molecular interactions that regulate commitment to B cell memory, the germinal centre reaction and the generation of memory plasma cells following antigen recall.

    • Michael McHeyzer-Williams
    • Shinji Okitsu
    • Louise McHeyzer-Williams
    Reviews
    Nature Reviews Immunology
    Volume: 12, P: 24-34

  • Complexities in sample handling, instrument setup and data analysis are barriers to the effective use of flow cytometry to monitor immunological parameters in clinical trials. The novel use of a central laboratory may help mitigate these issues.

    • Holden T Maecker
    • J Philip McCoy Jr
    • Jung-Hua Yeh
    Comments & Opinion
    Nature Immunology
    Volume: 11, P: 975-978

  • Research into the immune mechanisms associated with healthy tolerance to common foods, the inflammatory response underlying food allergies, and immunotherapy-induced desensitization promises new approaches to the diagnosis, prevention and treatment of food allergy.

    • Wong Yu
    • Deborah M. Hussey Freeland
    • Kari C. Nadeau
    Reviews
    Nature Reviews Immunology
    Volume: 16, P: 751-765

  • IgE provides protective immunity against helminths, but is also involved in the pathogenesis of allergic diseases. In this Review, Wu and Zarrin discuss recent studies using different IgE reporter mice, as well as other genetically modified mice, that have provided new insights on the cells and pathways involved in the production and regulation of IgE, and highlight the areas in need of additional studies.

    • Lawren C. Wu
    • Ali A. Zarrin
    Reviews
    Nature Reviews Immunology
    Volume: 14, P: 247-259

  • This article aims to make the methodology behind the recent spate of papers reportingin situimmune-cell imaging more accessible to the reader and to highlight potential artefacts so that the reader can analyse the data more critically.

    • Ronald N. Germain
    • Mark J. Miller
    • Michel C. Nussenzweig
    Reviews
    Nature Reviews Immunology
    Volume: 6, P: 497-507