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Showing 1–5 of 5 results
Advanced filters: Author: "Mark Groudine" Clear advanced filters

  • A new study provides compelling evidence that transcriptional regulation and three-dimensional genomic architecture are linked. The alpha- and beta-globin loci associate with hundreds of active genes across the genome at transcription factories in erythroid cells, and specialized Klf1-containing transcription factories mediate the association of Klf1-regulated genes.

    • Tobias Ragoczy
    • Mark Groudine
    News & Views
    Nature Genetics
    Volume: 42, P: 16-17

  • Genome-scale methods are providing increasingly detailed views of nucleosome organization and chromatin structure. This is enhancing our understanding of how DNA-based reactions occur in the context of chromatin and how they are influenced by genome accessibility.

    • Oliver Bell
    • Vijay K. Tiwari
    • Dirk Schübeler
    Reviews
    Nature Reviews Genetics
    Volume: 12, P: 554-564

  • The cellular transcription, mRNA processing and export machineries seem to have co-evolved to allow spatiotemporal coupling of these processes. Here, the author reviews recent insights into the relative amount of co-transcriptional and post-transcriptional processing, the relationship between mRNA elongation and processing, and the regulating role of the carboxy-terminal domain of RNA polymerase II.

    • David L. Bentley
    Reviews
    Nature Reviews Genetics
    Volume: 15, P: 163-175