Grant McFadden and colleagues discuss how the interferons and tumour necrosis factor can establish an intracellular antiviral state that determines the specificity of a particular virus for a specific cell type, tissue or species. Our knowledge of these antiviral cytokines can be exploited to enhance immunity against zoonotic infections and to improve the therapeutic specificity of tumour-targeted viruses.
- Grant McFadden
- Mohamed R. Mohamed
- Eric Bartee
