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Showing 1–17 of 17 results
Advanced filters: Author: "Mathias Jucker" Clear advanced filters

  • Credible evidence suggests that, under extraordinary circumstances, Alzheimer’s disease may be transmitted by a prion-like mechanism — yielding insights into both the basic biology of this neurodegenerative disorder and strategies for early prevention.

    • Mathias Jucker
    • Lary C. Walker
    News & Views
    Nature Medicine
    Volume: 30, P: 344-345

  • The prion paradigm – the hypothesis that the seeded aggregation of certain proteins is key to understanding age-related neurodegenerative disorders – is evaluated in relation to recent studies and disease models; the paradigm suggests a unifying pathogenic principle with broad relevance to a large class of currently intractable diseases.

    • Mathias Jucker
    • Lary C. Walker
    Reviews
    Nature
    Volume: 501, P: 45-51

  • The authors show that plasma levels of NfL increase with age in humans and are associated with mortality in nonagenarians and centenarians. In mice, a life-extending dietary restriction manipulation attenuated the similar age-related increase in plasma NfL levels.

    • Stephan A. Kaeser
    • Benoit Lehallier
    • Mathias Jucker
    Research
    Nature Aging
    Volume: 1, P: 218-225

  • Misfolded Aβ proteins can form proteopathic seeds that drive initiation, progression, and spreading of amyloidosis in the brain. Jucker and colleagues report that Aβ seeds can persist in mouse brain for months in the absence of host-derived Aβ and can then regain propagative and pathogenic activity in the presence of host Aβ.

    • Lan Ye
    • Sarah K Fritschi
    • Mathias Jucker
    Research
    Nature Neuroscience
    Volume: 18, P: 1559-1561

  • The sustained metabolic activation of the brain's default-mode network is thought to render the system vulnerable to Alzheimer's disease. Recent results with transgenic mice support this view by linking neuronal activity to interstitial fluid amyloid-β levels and the development of amyloid-β plaques.

    • Lary C Walker
    • Mathias Jucker
    News & Views
    Nature Neuroscience
    Volume: 14, P: 669-670

  • People who died of the neurodegenerative condition Creutzfeldt-Jakob disease after treatment with cadaver-derived human growth hormone also developed some of the pathological traits of Alzheimer's disease. See Letter p.247

    • Mathias Jucker
    • Lary C. Walker
    News & Views
    Nature
    Volume: 525, P: 193-194

  • Neocortical resident microglia are long-lived cells. Füger et al. report that approximately half of these cells survive for the entire lifespan of a mouse. While microglial proliferation under homeostatic conditions is low, proliferation is increased in a mouse model of Alzheimer's disease.

    • Petra Füger
    • Jasmin K Hefendehl
    • Mathias Jucker
    Research
    Nature Neuroscience
    Volume: 20, P: 1371-1376

  • The misfolding and aggregation of specific proteins — a process known as amyloidogenesis — seem to underlie a range of degenerative disorders. Here, Kelly and colleagues discuss the current understanding of the process and pathological role of protein aggregation, focusing on emerging disease-modifying strategies to ameliorate aggregation-associated degenerative disorders.

    • Yvonne S. Eisele
    • Cecilia Monteiro
    • Jeffery W. Kelly
    Reviews
    Nature Reviews Drug Discovery
    Volume: 14, P: 759-780