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Showing 1–3 of 3 results
Advanced filters: Author: "Mathieu Coureuil" Clear advanced filters

  • Meningococcus utilizes β-arrestin selective activation of endothelial cell β2 adrenergic receptor (β2AR) to cause meningitis in humans. Here authors report that Meningococcus triggers β2AR signaling by exerting forces on β2AR glycans that terminally expose N-acetyl-neuraminic acid (sialic acid, Neu5Ac) residues.

    • Zoe Virion
    • Stéphane Doly
    • Stefano Marullo
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • Bacteria have to overcome many obstacles to invade the meninges from the bloodstream. This Review considers how extracellular pathogens such asNeisseria meningitides and Streptococcus pneumoniaebypass the blood–brain barriers, the understanding of which may lead to improved methods for delivering drugs into the brain.

    • Mathieu Coureuil
    • Hervé Lécuyer
    • Xavier Nassif
    Reviews
    Nature Reviews Microbiology
    Volume: 15, P: 149-159