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Showing 1–5 of 5 results
Advanced filters: Author: "Matthew C Kiernan" Clear advanced filters

  • In 2017, dramatic advances have been made in the treatment of motor neuron diseases. New therapies have been approved for spinal muscular atrophy and amyotrophic lateral sclerosis, and a host of other therapies that are currently under development are showing promising results.

    • Matthew C. Kiernan
    News & Views
    Nature Reviews Neurology
    Volume: 14, P: 65-66

  • In this article, Loy and colleagues examine the case of a woman with frontotemporal dementia who presented in the clinic with complex delusions. Psychosis is considered an unusual early feature of this form of dementia but, when present, can wrongly suggest a diagnosis of schizophrenia. In discussing the case, Loyet al. highlight the clinical features that might assist in the differentiation between these two conditions.

    • Clement T. Loy
    • Jillian J. Kril
    • John R. Hodges
    Reviews
    Nature Reviews Neurology
    Volume: 6, P: 175-179

  • The symptoms and neuropathology of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) can show a high degree of overlap, and few effective treatments exist for these conditions. In this Perspectives article, Ittner and colleagues describe recent failures in the translation of data from mouse models into clinical trials for patients with FTD and/or ALS. The authors summarize the strengths and weaknesses of several available mouse models, and make recommendations for improving future research practice.

    • Lars M. Ittner
    • Glenda M. Halliday
    • Matthew C. Kiernan
    Reviews
    Nature Reviews Neurology
    Volume: 11, P: 360-366

  • Evidence is accumulating that cortical dysfunction — in particular, cortical hyperexcitability — is an early feature of amyotrophic lateral sclerosis (ALS), thereby lending support to the 'dying-forward' hypothesis of ALS pathogenesis. The authors present an overview of recent insights into ALS pathophysiology, focusing on the importance of cortical hyperexcitability as a pathogenic and diagnostic biomarker.

    • Nimeshan Geevasinga
    • Parvathi Menon
    • Steve Vucic
    Reviews
    Nature Reviews Neurology
    Volume: 12, P: 651-661

  • Chronic kidney disease is a serious global health problem, and almost all patients with severe forms of the disease develop neurological complications, which can include cognitive impairment, cerebrovascular disease and peripheral neuropathies. Krishnan and Kiernan review the clinical features and pathophysiology of the most common neurological complications of chronic kidney disease, and highlight the currently available treatment options.

    • Arun V. Krishnan
    • Matthew C. Kiernan
    Reviews
    Nature Reviews Neurology
    Volume: 5, P: 542-551