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Showing 1–3 of 3 results
Advanced filters: Author: "Matti Pirinen" Clear advanced filters

  • The human plasma lipidome captures risk for cardiometabolic diseases. Here, the authors perform univariate and multivariate genome-wide analyses of 179 lipid species in 7174 Finnish individuals, revealing genetic links between diseases and lipid species beyond the standard lipids HDL-Cholesterol, LDL-Cholesterol, Triglycerides, and total Cholesterol.

    • Linda Ottensmann
    • Rubina Tabassum
    • Matti Pirinen
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • Peter Donnelly and colleagues report an analysis considering the inclusion of non-confounding covariates within genome-wide association studies and provide software that can be used to assess the impact on power within a particular study. They find that, when the disease prevalence is low, including known covariates, such as sex or established genetic associations, can reduce the power to detect new associations.

    • Matti Pirinen
    • Peter Donnelly
    • Chris C A Spencer
    Research
    Nature Genetics
    Volume: 44, P: 848-851