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Showing 1–5 of 5 results
Advanced filters: Author: "Mauro Giacca" Clear advanced filters

  • The incidence of acute cardiovascular events, including myocardial infarction and ischemic stroke, is increased in individuals with COVID-19. A study shows that SARS-CoV-2 can directly infect macrophages and foam cells in atherosclerotic plaques and contribute to plaque instability.

    • Mauro Giacca
    News & Views
    Nature Cardiovascular Research
    Volume: 2, P: 966-967

  • Lungs from patients who died from COVID-19 show atypical fused cells, the formation of which is mediated by the SARS-CoV-2 spike protein, and drugs that inhibit TMEM16F can prevent spike-induced syncytia formation.

    • Luca Braga
    • Hashim Ali
    • Mauro Giacca
    Research
    Nature
    Volume: 594, P: 88-93

  • The transcription factor MYC upregulates and downregulates distinct sets of target genes, promoting cell growth and proliferation, increased metabolic rate and RNA biogenesis. This Review discusses MYC-mediated transcriptional regulation in normal growth control, as well as in tumour development and maintenance.

    • Theresia R. Kress
    • Arianna Sabò
    • Bruno Amati
    Reviews
    Nature Reviews Cancer
    Volume: 15, P: 593-607