The genomic landscape of testicular germ cell tumour (TGCT) risk is dominated by inherited genetic factors, which are highly polygenic in nature. Here, the authors discuss results from genome-wide association studies that have identified risk loci associated with TGCT risk.KIT–KITLGsignalling is currently the major pathway that is implicated in TGCT formation.
- Kevin Litchfield
- Max Levy
- Clare Turnbull