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Showing 1–7 of 7 results
Advanced filters: Author: "Mayumi Ito" Clear advanced filters

  • Nail stem cells (NSCs) reside in the proximal nail matrix, and early nail progenitors undergo Wnt-dependent differentiation into the nail; after amputation, Wnt activation is required for nail and digit regeneration, and amputations proximal to the Wnt-active nail progenitors fail to regenerate, but β-catenin stabilization in the NSC region induces regeneration.

    • Makoto Takeo
    • Wei Chin Chou
    • Mayumi Ito
    Research
    Nature
    Volume: 499, P: 228-232

  • Mayumi Ito and her colleagues show that during skin wounding in mice, melanocyte stem cells in the hair follicle are induced by melanocortin 1 receptor (Mc1r) signaling to migrate towards the epidermis and differentiate into mature pigment-producing cells. This mechanism allows for protection of the healing skin from ultraviolet light–induced damage.

    • Wei Chin Chou
    • Makoto Takeo
    • Mayumi Ito
    Research
    Nature Medicine
    Volume: 19, P: 924-929

  • Local microenvironmental cues modulate melanocyte stem cells, which control hair pigmentation, to enter different differentiation states, shifting between hair follicle stem cell and transit-amplifying compartments, a process that is different to other self-renewing systems.

    • Qi Sun
    • Wendy Lee
    • Mayumi Ito
    ResearchOpen Access
    Nature
    Volume: 616, P: 774-782

  • The distribution of skin immune cells, namely Langerhans cells (LCs) and dendritic epidermal T cells (DETCs), is well-documented, but the mechanisms underlying their pattern maintenance remained obscure. A study now finds that LCs maintain their distribution patterns depending upon Rac1 and that the density of LCs and DETCs is regulated by the density of epithelial cells.

    • Chae Ho Lim
    • Mayumi Ito
    News & Views
    Nature Cell Biology
    Volume: 23, P: 439-440

  • The microenvironment can regulate adult stem cell function during tissue homeostasis and regeneration, but whether and how this is altered in aging is unclear. Ichijo et al. find that increased dermal stiffness, as a result of vasculature atrophy, activates cation channel PIEZO1, leading to interfollicular epidermal stem cell dysregulation.

    • Chae Ho Lim
    • Mayumi Ito
    News & Views
    Nature Aging
    Volume: 2, P: 568-569

  • On wounding, scar formation in mammals arises causing no hair follicle regeneration, but it is unclear if scarring precludes regeneration. Here, the authors show that if Sonic hedgehog signaling is activated in the wound, an inductive dermal niche forms, enabling regeneration and hair follicle formation.

    • Chae Ho Lim
    • Qi Sun
    • Mayumi Ito
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13