Concentration gradients of certain molecules termed 'morphogens' are known to control tissue development during embryogenesis, but how exactly these gradients are formed remains unclear. Using the technique of fluorescence correlation spectroscopy, Fgf8 morphogen gradients are now shown to be established and maintained in living zebrafish by two essential factors: free diffusion of single molecules away from the source and a sink function of the receiving cells.
- Shuizi Rachel Yu
- Markus Burkhardt
- Michael Brand