Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–3 of 3 results
Advanced filters: Author: "Michael Doyle" Clear advanced filters

  • The synthesis of polycarbonyl compounds featuring four or more carbonyl groups is a synthetic challenge for organic chemists. Here, the authors describe how unsymmetric polycarbonyl compounds bearing up to 4 adjacent carbonyl groups can be accessed within a two-step synthesis from readily available starting materials and discuss their reactivity.

    • Luca De Angelis
    • Chao Pei
    • Michael P. Doyle
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-7

  • Chiral 3-azetidinones are structural analogues of medicinally relevant β-lactams, however their synthesis and reactivity are underexplored. Here, the authors show a highly enantioselective copper-catalyzed [3 + 1]-cycloaddition generating 2-azetidines, which react with nucleophiles yielding amino acids via 3-azetidinones.

    • Kostiantyn O. Marichev
    • Kuiyong Dong
    • Michael P. Doyle
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10

  • Microtubule-based mRNA transport participates in the establishment of cell asymmetries. An in vitro reconstitution assay demonstrates that localization signals present in an mRNA influence motor copy number on single RNA molecule cargoes, ultimately leading to highly polarized distributions of transcripts.

    • Michael Doyle
    • Michael A. Kiebler
    News & Views
    Nature Cell Biology
    Volume: 14, P: 333-335