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Showing 1–7 of 7 results
Advanced filters: Author: "Michael G. Rosenfeld" Clear advanced filters

  • The classical model of gene activation by a unidirectional switch from co-repressor binding to co-activator binding is changing. This Review discusses emerging themes in the interplay among co-repressor complexes, enzymatic functions and chromatin modifications in controlling gene repression.

    • Valentina Perissi
    • Kristen Jepsen
    • Michael G. Rosenfeld
    Reviews
    Nature Reviews Genetics
    Volume: 11, P: 109-123

  • A new study reveals that the HMG-box transcription factor SOX2 coupled with the chromatin remodeling helicase CHD7 cooperatively regulate target genes that are essential during neural stem cell development. Notably, this complex controls the expression of several disease-associated genes, suggesting a possible mechanistic connection between five seemingly unrelated human genetic disorders.

    • Janusz Puc
    • Michael G Rosenfeld
    News & Views
    Nature Genetics
    Volume: 43, P: 505-506

  • Recent evidence indicates that controlled generation of DNA breaks, accompanied by activation of DNA damage repair pathways, can regulate transcription through promoter and enhancer activation and the relief of DNA torsional stress.

    • Janusz Puc
    • Aneel K. Aggarwal
    • Michael G. Rosenfeld
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 18, P: 471-476

  • The observation that many, if not all, functional enhancers generate non-coding enhancer RNAs (eRNAs) has raised critical questions regarding the potential biological roles of the enhancer transcription process and, indeed, of eRNAs. This article reviews fundamental insights into the inter-regulation of enhancers and promoters and discusses unresolved questions regarding the functional role of enhancers as transcription units in genome regulation.

    • Wenbo Li
    • Dimple Notani
    • Michael G. Rosenfeld
    Reviews
    Nature Reviews Genetics
    Volume: 17, P: 207-223

  • MicroRNAs (miRNAs) have recently emerged as key regulators of metabolism. For example, miR-33a and miR-33b control cholesterol and lipid metabolism in concert with their host genes, the sterol-regulatory element-binding protein (SREBP) transcription factors. miRNAs also regulate insulin and glucose homeostasis. Thus, miRNAs may be potential therapeutic targets for ameliorating cardiometabolic disorders.

    • Veerle Rottiers
    • Anders M. Näär
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 13, P: 239-250