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Advanced filters: Author: "Michael J. Eck" Clear advanced filters

  • The crystal structure of the FERM-SH2 region of Tyk2 in complex with the cytoplasmic tail of an interferon-α receptor provides a first view of specific JAK-receptor recognition and reveals a central role of the heretofore-marginalized JAK SH2 domain in recognizing the cytokine-receptor box2 motif.

    • Randall McNally
    • Michael J Eck
    News & Views
    Nature Structural & Molecular Biology
    Volume: 21, P: 431-433

  • Focal adhesion kinase (FAK) is a scaffold and tyrosine kinase protein that binds to itself and cellular partners through its four-point-one, ezrin, radixin, moesin (FERM) domain. Recent structural work reveals how regulatory proteins activate FAK by binding to its FERM domain, enabling it to coordinate diverse cellular responses.

    • Margaret C. Frame
    • Hitesh Patel
    • Michael J. Eck
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 11, P: 802-814