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Showing 1–3 of 3 results
Advanced filters: Author: "Michael J. Owen" Clear advanced filters

  • Copy number variation has emerged as an important type of genetic risk factor for developmental disorders, including the neurodevelopmental disorders schizophrenia, autism and mental retardation. The highly pleiotropic effects observed for specific copy number variants (CNVs) challenge current classification of these disorders, but also provide opportunities to understand their origins and the relationships between them.

    • Michael C O'Donovan
    • George Kirov
    • Michael J Owen
    News & Views
    Nature Genetics
    Volume: 40, P: 1392-1393

  • Advances in the understanding of the genetic and environmental causes of schizophrenia, and their relationship to aberrant patterns of neurodevelopment, have led to growing interest in the possibility that 'disease-modifying' strategies could alter the course to — and of — this debilitating disorder, rather than just alleviating its symptoms. This article provides a broad-based consideration of the challenges and opportunities inherent in such efforts.

    • Mark J. Millan
    • Annie Andrieux
    • Daniel Weinberger
    Reviews
    Nature Reviews Drug Discovery
    Volume: 15, P: 485-515