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Showing 1–5 of 5 results
Advanced filters: Author: "Michael L. Dustin" Clear advanced filters

  • Increasing cholesterol levels in the cell membranes of killer T cells boosts the cells' ability to mount an immune response against tumour cells in mice. Such a strategy might be valuable in anticancer immunotherapies. See Letter p.651

    • Michael L. Dustin
    News & Views
    Nature
    Volume: 531, P: 583-584

  • Acute inhibition of the regulatory kinase Csk reveals additional checkpoints for full activation of thymocytes via the T cell antigen receptor.

    • Michael L Dustin
    • Simon J Davis
    News & Views
    Nature Immunology
    Volume: 15, P: 136-137

  • How the kinase PKC-θ is targeted to the immunological synapse and is activated once there remains unclear. A targeting motif in PKC-θ and the previously unsuspected kinase GLK identified in two separate papers now explains this.

    • Michael L Dustin
    News & Views
    Nature Immunology
    Volume: 12, P: 1031-1032

  • The priming of naive T cells requires antigen presentation by activated dendritic cells, yet the optimal generation of effector and memory CD8+ T cells requires subsequent T cell–T cell interactions during the critical differentiation period.

    • David A Blair
    • Michael L Dustin
    News & Views
    Nature Immunology
    Volume: 14, P: 311-312

  • Unexpected and controversial results regarding the functional organization of the T cell synapse have been obtained from the single molecule imaging techniques that have recently become available.

    • Michael L. Dustin
    • David Depoil
    Reviews
    Nature Reviews Immunology
    Volume: 11, P: 672-684