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Showing 1–4 of 4 results
Advanced filters: Author: "Michael Platten" Clear advanced filters

  • Immunotherapies activate T cells to destroy tumours, but the approach has failed in some brain cancers. A strategy to improve migration of T cells across the blood–brain barrier could overcome this limitation.

    • Michael Platten
    News & Views
    Nature
    Volume: 561, P: 319-320

  • This Review presents an overview of vaccine-based immunotherapies for human glioma. Although efficacy remains unproven for the vaccines in clinical development, Weller and colleagues highlight promising strategies for antagonizing glioma-associated immunosuppression and boosting immune responses in vaccinated patients. Ultimately, such approaches might help to control the growth of human gliomas.

    • Michael Weller
    • Patrick Roth
    • John H. Sampson
    Reviews
    Nature Reviews Neurology
    Volume: 13, P: 363-374

  • The DNA repair proteinO6-methylguanine-DNA methyltransferase (MGMT) might interfere with alkylating agent chemotherapy in patients with glioma or glioblastoma. In this Review, Wick and colleagues discuss how epigenetic silencing of the MGMT gene via promotor methylation is associated with improved response to chemotherapy, and with improved survival, in patients with glioblastoma and other gliomas. The authors also highlight the usefulness of MGMTpromotor methylation as a biomarker for both clinical practice and the design of treatment trials.

    • Wolfgang Wick
    • Michael Weller
    • Guido Reifenberger
    Reviews
    Nature Reviews Neurology
    Volume: 10, P: 372-385