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Advanced filters: Author: "Michael S. Wolfe" Clear advanced filters

  • Malfunction of presenilin enzymes, which cleave proteins in cell membranes, can lead to Alzheimer's disease. A crystal structure of a microbial presenilin provides insights into the workings of this enzyme family. See Article p.56

    • Michael S. Wolfe
    News & Views
    Nature
    Volume: 493, P: 34-35

  • Production of the amyloid-β peptide in Alzheimer's disease by the γ-secretase complex can be regulated by certain G protein–coupled receptors. This regulation seems to be mediated by β-arrestin-2, whose expression was found to be elevated in Alzheimer's disease brains (pages 43–49).

    • Michael S Wolfe
    News & Views
    Nature Medicine
    Volume: 19, P: 22-24