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Showing 1–9 of 9 results
Advanced filters: Author: "Michael Sixt" Clear advanced filters

  • Stromal cells in the subcapsular sinus of the lymph node 'decide' which cells and molecules are allowed access to the deeper parenchyma. The glycoprotein PLVAP is a crucial component of this selector function.

    • Miroslav Hons
    • Michael Sixt
    News & Views
    Nature Immunology
    Volume: 16, P: 338-340

  • During inflammation, lymph nodes swell with an influx of immune cells. New findings identify a signalling pathway that induces relaxation in the contractile cells that give structure to these organs. See Letter p.498

    • Kari Vaahtomeri
    • Michael Sixt
    News & Views
    Nature
    Volume: 514, P: 441-442

  • When cells migrate through complex 3D environments, as are most tissues, they encounter several challenges, including the need to adapt to changing biomechanical properties of the surroundings, squeezing through narrow passages and coordinating motion with other cells. A better understanding of 3D cell migration mechanisms provides key insights into development, tissue regeneration, immune responses and cancer cell dissemination.

    • Kenneth M. Yamada
    • Michael Sixt
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 20, P: 738-752

  • Leukocytes use different strategies to migrate through the endothelium of venular walls and in interstitial tissues. These strategies are regulated by soluble and cell-bound signals. Studies have identified many of the cellular and subcellular events that govern transendothelial migration and are beginning to elucidate the nature of leukocyte interstitial motility.

    • Sussan Nourshargh
    • Peter L. Hordijk
    • Michael Sixt
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 11, P: 366-378

  • Homologous recombination is crucial for genome stability and for genetic exchange. Our knowledge of homology search, the step in this process that explores the genome for homologous sequences to enable recombination, has been increased by recent methodological advances. These insights can be integrated into a mechanistic model of homology search.

    • Jörg Renkawitz
    • Claudio A. Lademann
    • Stefan Jentsch
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 15, P: 369-383

  • In this Review, the authors discuss the molecular mechanisms that enable B cells to internalize, process and present antigens on MHC class II molecules to CD4+T cells. They focus on the importance of cytoskeletal rearrangements and the establishment of polarity in B cells for these processes.

    • Maria-Isabel Yuseff
    • Paolo Pierobon
    • Ana-Maria Lennon-Duménil
    Reviews
    Nature Reviews Immunology
    Volume: 13, P: 475-486

  • The recirculation of lymphocytes through lymph nodes and their encounter with dendritic cells is crucial for immunity. Here, the authors review the role of high endothelial venules, lymphatics and lymph node stroma in the trafficking of immune cells in lymph nodes during homeostasis.

    • Jean-Philippe Girard
    • Christine Moussion
    • Reinhold Förster
    Reviews
    Nature Reviews Immunology
    Volume: 12, P: 762-773