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Showing 1–14 of 14 results
Advanced filters: Author: "Michael Snyder" Clear advanced filters

  • Protein-chip technology is a powerful tool for high-throughput assays of protein profiling, protein–DNA interactions and enzyme activity. Improvements in the technology, such as the construction of whole-proteome arrays in yeast, could lead to the description of comprehensive interaction maps in many organisms.

    • Li A. Kung
    • Michael Snyder
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 7, P: 617-622

  • The development of high-throughput DNA sequencing methods provides a new method for mapping and quantifying transcriptomes — RNA sequencing (RNA-Seq). This article explains how RNA-Seq works, the challenges it faces and how it is changing our view of eukaryotic transcriptomes.

    • Zhong Wang
    • Mark Gerstein
    • Michael Snyder
    Reviews
    Nature Reviews Genetics
    Volume: 10, P: 57-63

  • Yeast has been engineered so that the binding of small-molecule ligands to a target protein can be simply detected by changes in growth.

    • Susana Vidan
    • Michael Snyder
    News & Views
    Nature Biotechnology
    Volume: 19, P: 1022-1023

  • Many cellular functions are carried out by proteins that are bound together in complexes. In two new large-scale studies, labelled proteins are used as 'bait' to capture and identify those complexes.

    • Anuj Kumar
    • Michael Snyder
    News & Views
    Nature
    Volume: 415, P: 123-124

  • Understanding how gene expression is regulated on a global scale is important for determining how basic processes such as cell proliferation, cell differentiation and responses to environmental signals are controlled. Three papers now show that it is possible to identify binding sites for key transcription factors in human cells on a chromosome level.

    • Ghia Euskirchen
    • Michael Snyder
    News & Views
    Nature Genetics
    Volume: 36, P: 325-326

  • The next step after sequencing a genome is to figure out how the cell actually uses it as an instruction manual. A large international consortium has examined 1% of the genome for what part is transcribed, where proteins are bound, what the chromatin structure looks like, and how the sequence compares to that of other organisms.

    • Ewan Birney
    • John A. Stamatoyannopoulos
    • Pieter J. de Jong
    Research
    Nature
    Volume: 447, P: 799-816

  • Most of the human genome consists of non-protein-coding DNA. This article describes the progress made in annotating this non-coding portion of the genome by combining data from comparative and functional genomics analyses.

    • Roger P. Alexander
    • Gang Fang
    • Mark B. Gerstein
    Reviews
    Nature Reviews Genetics
    Volume: 11, P: 559-571