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Showing 1–5 of 5 results
Advanced filters: Author: "Michail Ignatiadis" Clear advanced filters

  • A recent study of 843 patients from three hospitals that compared the assessment of HER2 status using FDA-approved immunohistochemistry and fluorescence in situ hybridization assays versus a quantitative reverse transcription PCR (qRT-PCR) assay by Oncotype DX®, showed a high false negative rate for the qRT-PCR assay.

    • Michail Ignatiadis
    • Christos Sotiriou
    News & Views
    Nature Reviews Clinical Oncology
    Volume: 9, P: 12-14

  • Liquid biopsy assays have the potential to revolutionize the diagnosis and management of cancer, and rapid progress is being made in the clinical translation of such assays. This Perspective outlines notable advances in the use of liquid biopsy technologies in the management of solid tumours, as well as future research avenues, clinical trial methodologies and implementation logistics for the eventual integration of liquid biopsy into the clinical workflow.

    • Michail Ignatiadis
    • George W. Sledge
    • Stefanie S. Jeffrey
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 18, P: 297-312

  • Luminal breast cancer is the most-frequently occurring subtype of breast cancer, but it is a highly heterogeneous disease. Data are emerging to assist in the stratification of patients to the optimal treatment and to address therapy resistance. This Review outlines the biology of this disease, and discusses the treatment options and ongoing studies for women with oestrogen receptor-positive breast cancer.

    • Michail Ignatiadis
    • Christos Sotiriou
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 10, P: 494-506