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Showing 1–2 of 2 results
Advanced filters: Author: "Michel E Safar" Clear advanced filters

  • Developments in the interpretation of blood pressure curves have enabled assessment of pressure-wave reflections and arterial stiffness in the vascular system. These measurements can be translated into assessment of cardiovascular risk, enabling new features of cardiovascular disease and new drug treatments to be investigated. Here, the structural and functional factors that influence arterial stiffness are discussed.

    • Jacques Blacher
    • Michel E Safar
    Reviews
    Nature Clinical Practice Cardiovascular Medicine
    Volume: 2, P: 450-455

  • Aging is accompanied by changes in vascular structure and function leading to arterial stiffness, which is an important predictor of cardiovascular disease. Hemodynamic changes associated with arterial aging include increased pulse pressure, pulse wave velocity, and wave reflection. In this Review, Michel Safar describes the features of arterial aging, and how blockade of the renin–angiotensin–aldosterone system may ameliorate the effects of this process.

    • Michel E. Safar
    Reviews
    Nature Reviews Cardiology
    Volume: 7, P: 442-449