Tumour cells can evade the immune response through different strategies, with the tumour microenvironment being a key determinant of which pathways become activated to restrain antitumour immunity. The authors of this Review describe the four major types of therapeutic interventions required in combinations to generate a strong antitumour response. Importantly, they also discuss which combination therapies might effectively engage immunity to suppress tumour progression in four different scenarios defined by the composition of the immune tumour microenvironment.
- Mark J. Smyth
- Shin Foong Ngiow
- Michele W. L. Teng
