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Showing 1–3 of 3 results
Advanced filters: Author: "Miguel A. Lanaspa" Clear advanced filters

  • SGLT2 inhibitors have shown great promise in the management of diabetes mellitus and the prevention of cardiovascular complications, but increasing evidence suggests that their use can be associated with an increased risk of acute kidney injury. Insights into the mechanisms involved might help to identify individuals who are at risk of renal injury.

    • Kai Hahn
    • A. Ahsan Ejaz
    • Richard J. Johnson
    Comments & Opinion
    Nature Reviews Nephrology
    Volume: 12, P: 711-712

  • The underlying cause of hypertension is unknown in the vast majority of patients with high blood pressure. This Perspectives article discusses the role of T cells in renal inflammation and how autoimmunity, mediated by heat shock proteins, leads to salt-sensitive hypertension.

    • Bernardo Rodríguez-Iturbe
    • Héctor Pons
    • Richard J. Johnson
    Reviews
    Nature Reviews Nephrology
    Volume: 10, P: 56-62

  • Recurrent dehydration and salt loss might be a mechanism that causes chronic kidney disease, whereby increased plasma osmolarity activates both intrarenal (polyol-fructokinase) and extrarenal (vasopressin) pathways to drive injury. The authors propose that water and salt influence blood pressure through the timing and combination of their intake, affecting plasma osmolarity and intrarenal and extrarenal mechanisms of renal injury.

    • Richard J. Johnson
    • Bernardo Rodriguez-Iturbe
    • Laura G. Sanchez-Lozada
    Reviews
    Nature Reviews Nephrology
    Volume: 10, P: 415-420