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Showing 1–12 of 12 results
Advanced filters: Author: "Mihai G. Netea" Clear advanced filters

  • In this Viewpoint article,Nature Reviews Immunologyinvites five experts to discuss the nature of immunological memory. How should we define a memory response? And can innate immune cells — as well as lymphocytes — develop into memory populations? The contributors share their thoughts on these questions and other key issues in the field.

    • Donna L. Farber
    • Mihai G. Netea
    • Rolf M. Zinkernagel
    Reviews
    Nature Reviews Immunology
    Volume: 16, P: 124-128

  • Little is known about the regulatory mechanisms of antifungal host defense. Two complementary studies show that the E3 ubiquitin ligase CBLB targets dectin-1 and dectin-2 for degradation, and thus exerts a strong anti-inflammatory effect.

    • Frank L van de Veerdonk
    • Mihai G Netea
    News & Views
    Nature Medicine
    Volume: 22, P: 834-835

  • Susceptibility to Crohn's disease has been linked to polymorphisms in genes involved in two pathophysiological pathways: autophagy and the recognition of bacterial peptidoglycan by nucleotide oligomerization domain-2 (NOD2), an intracellular receptor. Two studies link these pathways by showing that recognition of bacterial peptidoglycans by NOD2 induces autophagy and bacterial clearance.

    • Mihai G Netea
    • Leo A B Joosten
    News & Views
    Nature Medicine
    Volume: 16, P: 28-30

  • The cell-surface receptor TREML4 amplifies cellular responses to single-stranded RNA by regulating recruitment of the adaptor MyD88 to the receptor TLR7. Mice lacking TREML4 show impaired antiviral immunity but also reduced severity of lupus-like disease.

    • Mihai G Netea
    • Frank L van de Veerdonk
    News & Views
    Nature Immunology
    Volume: 16, P: 445-446

  • Clinical evidence, including results from randomized controlled clinical trials, strongly suggests that certain live vaccines can reduce all-cause mortality, most probably through protection against non-targeted pathogens. This Opinion article examines the potential immunological mechanisms underlying these effects.

    • Helen S. Goodridge
    • S. Sohail Ahmed
    • Christopher B. Wilson
    Reviews
    Nature Reviews Immunology
    Volume: 16, P: 392-400

  • Researchers gathered at the Wellcome Trust Genome Campus in Hinxton, Cambridge, for the first Innate Immune Memory Conference dedicated to the adaptive characteristics of innate immunity, to further the understanding of this newly described immunological process that probably has a central role in host defense and inflammation.

    • Mihai G Netea
    • Eicke Latz
    • Luke A J O'Neill
    News & Views
    Nature Immunology
    Volume: 16, P: 675-679

  • This Review describes the host immune response toCandida fungal infections. The authors detail the innate and adaptive immune mechanisms, as well as the non-immune mechanisms, that are involved in the antifungal response. They also discuss emerging evidence suggesting that both innate and adaptive immune cells contribute to immune memory against Candidaspecies.

    • Mihai G. Netea
    • Leo A. B. Joosten
    • Frank L. van de Veerdonk
    Reviews
    Nature Reviews Immunology
    Volume: 15, P: 630-642

  • Aspergillus fumigatusis an environmental fungus that can cause life-threatening disease. In this Review, van de Veerdonk and colleagues describe howA. fumigatusadapts to environmental change, mechanisms of host defence and our current knowledge of the interplay between the host immune response and the fungus.

    • Frank L. van de Veerdonk
    • Mark S. Gresnigt
    • Jean-Paul Latgé
    Reviews
    Nature Reviews Microbiology
    Volume: 15, P: 661-674

  • Sepsis — which is caused by a dysregulated host response to infection — is a life-threatening organ dysfunction. This Review describes the recent advances in our understanding of sepsis pathogenesis and discusses strategies for the development of successful therapies.

    • Tom van der Poll
    • Frank L. van de Veerdonk
    • Mihai G. Netea
    Reviews
    Nature Reviews Immunology
    Volume: 17, P: 407-420

  • Candida albicanscan grow as unicellular budding yeast cells and as filamentous hyphae. Mihai Netea and colleagues discuss the molecular mechanisms that drive this dimorphism, the changes that lead to differential interaction with the host, and the immunological mechanisms that discriminate between tissue colonization and invasion.

    • Neil A. R. Gow
    • Frank L. van de Veerdonk
    • Mihai G. Netea
    Reviews
    Nature Reviews Microbiology
    Volume: 10, P: 112-122

  • In the past few years, substantial progress has been made in our understanding of the role of Toll-like receptors (TLRs) in inflammatory diseases. Joosten and colleagues discuss the role of TLRs in the pathophysiology of rheumatic diseases and how TLRs and TLR signalling pathways can be targeted to treat these conditions.

    • Leo A. B. Joosten
    • Shahla Abdollahi-Roodsaz
    • Mihai G. Netea
    Reviews
    Nature Reviews Rheumatology
    Volume: 12, P: 344-357