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Showing 1–8 of 8 results
Advanced filters: Author: "Ming-Hu Han" Clear advanced filters

  • Optogenetic induction of phasic, but not tonic, firing in VTA dopamine neurons induces susceptibility to stress in mice undergoing a subthreshold social-defeat paradigm and in previously resilient mice that have been subjected to repeated social-defeat stress, and this effect is projection-pathway specific.

    • Dipesh Chaudhury
    • Jessica J. Walsh
    • Ming-Hu Han
    Research
    Nature
    Volume: 493, P: 532-536

  • Chronic social-defeat stress increases phasic firing of ventral tegmental area (VTA) neurons and increases the amount of BDNF in the nucleus accumbens (NAc). The authors show that increased activity of NAc-projecting VTA neurons is sufficient to increase the amount of BDNF in the NAc, an effect that depends on CRF signaling in the NAc.

    • Jessica J Walsh
    • Allyson K Friedman
    • Ming-Hu Han
    Research
    Nature Neuroscience
    Volume: 17, P: 27-29

  • Potassium channels in the ventral tegmental area are known to regulate resilience against stress-induced depression. Here, the authors show over expression of KCNQ3 channels in VTA dopaminergic neurons or treatment with KCNQ channel openers normalizes depressive behaviours in mouse models.

    • Allyson K. Friedman
    • Barbara Juarez
    • Ming-Hu Han
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-7

  • Sex differences in reward processing are at present poorly understood. Calipari and Juarezet al. report oestrous cycle-dependent fluctuations in firing of VTA dopamine neurons that drive alterations in DAT function expressed in terminals in the NAc. These differences underlie enhanced cocaine reward processing during oestrus.

    • Erin S. Calipari
    • Barbara Juarez
    • Eric J Nestler
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15

  • Mice exposed to a two-bottle alcohol choice paradigm can be divided into high and low drinking groups. Here, the authors show that stimulating VTA neurons to induce higher phasic activity patterns that are observed in low alcohol drinking mice, suppresses alcohol drinking in mice that are high alcohol drinking.

    • Barbara Juarez
    • Carole Morel
    • Ming-Hu Han
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15