Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–8 of 8 results
Advanced filters: Author: "Modesto Orozco" Clear advanced filters

  • The p38α protein kinase is an attractive druggable target for many human diseases. Here, the authors show how the structural plasticity of p38α can be leveraged to selectively inhibit a subset of the functions regulated by this kinase and aid in the development of therapeutic compounds.

    • Lorena González
    • Lucía Díaz
    • Angel R. Nebreda
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • Multi-layered epigenetic regulation in higher eukaryotes makes it challenging to disentangle the individual effects of modifications on chromatin structure and function. Here, the authors expressed mammalian DNA methyltransferases in yeast, which have no DNA methylation, to show that methylation has intrinsic effects on chromatin structure.

    • Diana Buitrago
    • Mireia Labrador
    • Modesto Orozco
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • Functional changes in protein structures are involved in a large number of biochemical processes. Here, the authors perform a simulation study of known protein structures to show how β-sheets possess the ability to facilitate concerted backbone motions.

    • R. Bryn Fenwick
    • Laura Orellana
    • Xavier Salvatella
    Research
    Nature Communications
    Volume: 5, P: 1-9

  • DNAzymes are attractive catalysts for biomedical and biotechnological applications, but their catalytic mechanism remained obscure. This work investigates the detailed reaction mechanism of RNA ligation catalysed by the 9DB1 DNAzyme, revealing that it resembles those of natural protein enzymes.

    • Juan Aranda
    • Montserrat Terrazas
    • Modesto Orozco
    Research
    Nature Catalysis
    Volume: 2, P: 544-552

  • Parmbsc1, a new force field for DNA simulations, was broadly tested on nearly 100 DNA systems and overcame simulation artifacts that affected previous force fields.

    • Ivan Ivani
    • Pablo D Dans
    • Modesto Orozco
    Research
    Nature Methods
    Volume: 13, P: 55-58