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Showing 1–12 of 12 results
Advanced filters: Author: "Mohamed Lamkanfi" Clear advanced filters

  • The NLRP1b inflammasome activation may lead to pyroptosis and secretion of the inflammatory cytokines IL-1ß and IL-18 but the mechanisms behind these processes are not fully understood. Here, the authors show that they can occur independently of the inflammasome adaptor ASC and without caspase-1 autoprocessing.

    • Nina Van Opdenbosch
    • Prajwal Gurung
    • Mohamed Lamkanfi
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-14

  • The NLRP3 inflammasome has broad biomedical relevance, but its activation mechanisms are incompletely understood. NEK7, a kinase that regulates microtubules during mitosis, is identified as a critical and selective upstream regulator of NLRP3 inflammasome activation.

    • Filip Van Hauwermeiren
    • Mohamed Lamkanfi
    News & Views
    Nature Immunology
    Volume: 17, P: 223-224

  • Inflammasomes are central instigators of the inflammatory response to infection and tissue damage and key regulators in diverse diseases. Here, the authors describe signalling mechanisms that regulate the NLRP3 inflammasome pathways and recent progress in the development of inhibitors and agonists that are advancing into the clinic.

    • Lieselotte Vande Walle
    • Mohamed Lamkanfi
    Reviews
    Nature Reviews Drug Discovery
    Volume: 23, P: 43-66

  • Recent studies have shown that caspase 1 activation by inflammasomes controls a set of non-canonical effector mechanisms that might contribute to the immune response during infection and autoimmunity. These mechanisms include unconventional protein secretion, pyroptosis, regulation of metabolic pathways and restriction of bacterial replication.

    • Mohamed Lamkanfi
    Reviews
    Nature Reviews Immunology
    Volume: 11, P: 213-220

  • The adaptor ASC functions in inflammasome assembly. Kanneganti and colleagues show that ASC has an inflammasome-independent role in regulating the stability of Dock2 mRNA and thereby governs the chemotaxis and phagocytosis of cells of the immune response.

    • Sirish K Ippagunta
    • R K Subbarao Malireddi
    • Thirumala-Devi Kanneganti
    Research
    Nature Immunology
    Volume: 12, P: 1010-1016

  • The discovery of the inflammasome protein complex in 2002 was a breakthrough in our understanding of how the immune system triggers inflammation. Now researchers are attempting to modulate its activity to treat disease.

    • Mohamed Lamkanfi
    • Vishva M. Dixit
    News & Views
    Nature
    Volume: 548, P: 534-535

  • Intestinal infection with rotavirus is a major cause of diarrhoea in infants, and can be fatal. The identification of immune sensor proteins that detect and restrict this viral infection now illuminates the body's defence system. See Letter p.667

    • Pedro H. V. Saavedra
    • Mohamed Lamkanfi
    News & Views
    Nature
    Volume: 546, P: 606-608