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Showing 1–6 of 6 results
Advanced filters: Author: "Moosa Mohammadi" Clear advanced filters

  • Structural data has provided insight into the molecular mechanisms that modulate fibroblast growth factor (FGF) signalling to generate distinct biological outputs in development, tissue homeostasis and metabolism. Mechanisms include alternative splicing of ligand and receptor, homodimerization and site-specific proteolytic cleavage of ligand, and interaction of ligand and receptor with heparan sulphate and Klotho co-receptors.

    • Regina Goetz
    • Moosa Mohammadi
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 14, P: 166-180

  • X-ray crystallography, solution NMR and biochemical and cell-based analyses reveal a model where catalytically repressed receptor tyrosine kinases accomplish activation loop (A-loop) tyrosine transphosphorylation.

    • Lingfeng Chen
    • William M. Marsiglia
    • Moosa Mohammadi
    Research
    Nature Chemical Biology
    Volume: 16, P: 267-277

  • The central roles of members of the fibroblast growth factor (FGF) family in human developmental processes and disease have been well documented. In their Review, Beenken and Mohammadi discuss the more established applications of FGF-related therapies in the treatment of cancer and cardiovascular disease, emphasizing their potential to modulate aspects of the metabolic syndrome and hypophosphataemic diseases.

    • Andrew Beenken
    • Moosa Mohammadi
    Reviews
    Nature Reviews Drug Discovery
    Volume: 8, P: 235-253

  • Adiponectin and fibroblast growth factor 21 (FGF21) regulate glucose and lipid metabolism in similar ways and are both critically involved in the antidiabetic effects of thiazolidinedione drugs. Studies in mice now shed light on how adiponectin and FGF21 are functionally linked, which has intriguing implications for the therapeutic potential of these hormones.

    • Regina Goetz
    News & Views
    Nature Reviews Endocrinology
    Volume: 9, P: 506-508

  • Fibroblast growth factor signalling pathways have crucial roles in the development and maintenance of healthy cartilage. In this Review, the authors discuss strategies for targeting these pathways in osteoarthritis and cartilage repair.

    • Yangli Xie
    • Allen Zinkle
    • Moosa Mohammadi
    Reviews
    Nature Reviews Rheumatology
    Volume: 16, P: 547-564