Amyloidosis is caused by the aggregation of insoluble fibrous deposits of misfolded proteins. Cardiac deposition can lead to diastolic dysfunction, arrhythmias, and ischaemia. In this Review, Gertz et al. summarize the pathophysiology of the condition, and how best to achieve early diagnosis and treatment, before advanced heart failure occurs.
- Morie A. Gertz
- Angela Dispenzieri
- Taimur Sher
