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Showing 1–10 of 10 results
Advanced filters: Author: "Murat Gunel" Clear advanced filters

  • Murat Günel and colleagues identify recurrent mutations in POLR2A, which encodes the catalytic subunit of RNA polymerase II, in a subset of meningiomas. They find that POLR2A-mutant tumors can be distinguished on the basis of their super-enhancer and gene expression profiles, which show dysregulation of key meningeal identity genes.

    • Victoria E Clark
    • Akdes Serin Harmancı
    • Murat Günel
    Research
    Nature Genetics
    Volume: 48, P: 1253-1259

  • Murat Günel and colleagues use an integrated genomic approach to analyze the malignant progression of IDH1-mutant gliomas. They observe nonlinear clonal expansion of the original tumors and identify oncogenic pathways driving progression, including activation of MYC and RTK-RAS-PI3K pathways and epigenetic silencing of developmental transcription factors.

    • Hanwen Bai
    • Akdes Serin Harmancı
    • Murat Günel
    Research
    Nature Genetics
    Volume: 48, P: 59-66

  • Meningiomas are mostly benign brain tumours with the potential for becoming atypical or malignant. Here, the authors show that primary atypical meningiomas are epigenetically and genetically distinct from benign and progressed tumours, highlighting possible therapeutic targets such as PRC2.

    • Akdes Serin Harmancı
    • Mark W. Youngblood
    • Murat Günel
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14

  • After three decades of work, hypothesis-generating genomic approaches have led to the identification of several intracranial aneurysm risk loci and Mendelian mutations, involving several unexpected genes. These findings opened the door for exciting opportunities, unraveling the genomic architecture of brain aneurysms. The field is now ripe to face the next set of surprises in this long journey.

    • Tanyeri Barak
    • Murat Günel
    Comments & Opinion
    Nature Cardiovascular Research
    Volume: 1, P: 281-282

  • Richard Lifton and colleagues report the identification of three susceptibility loci for intracranial aneurysm. Two of the loci are new, with SNPs on chromosome 8q likely acting through SOX17, which is required for the formation and maintenance of endothelial cells.

    • Kaya Bilguvar
    • Katsuhito Yasuno
    • Murat Günel
    Research
    Nature Genetics
    Volume: 40, P: 1472-1477

  • Mapping disease loci that underlie putative Mendelian forms of malformations of cortical development is complicated by genetic heterogeneity, small family sizes and diagnostic classifications that may not reflect molecular pathogenesis. These authors use whole-exome sequencing to identify recessive mutations in WDR62 as the cause of a wide spectrum of severe cerebral cortical malformations. WDR62's nuclear localization to germinal neuroepithelia indicates that cortical malformations can be caused by events during progenitor proliferation and neurogenesis.

    • Kaya Bilgüvar
    • Ali Kemal Öztürk
    • Murat Günel
    Research
    Nature
    Volume: 467, P: 207-210