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  • The backbones of all natural peptides and proteins are composed of amide bonds. In the laboratory, the construction of such bonds generally relies on dehydrative approaches, although there are alternatives. It is now shown that the activation of amines and nitroalkanes with an electrophilic iodine source can lead directly to amide products.

    • Bo Shen
    • Dawn M. Makley
    • Jeffrey N. Johnston
    Research
    Nature
    Volume: 465, P: 1027-1032