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Showing 1–5 of 5 results
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  • The ‘CoINPocket’ approach identifies pharmacological similarities between G protein–coupled receptors. On the basis of predicted pharmacological similarity to a few phylogenetically unrelated receptors, the approach identified surrogate ligands for the orphan receptor GPR37L1.

    • Tony Ngo
    • Andrey V Ilatovskiy
    • Nicola J Smith
    Research
    Nature Chemical Biology
    Volume: 13, P: 235-242

  • In fragile X syndrome, the absence of fragile X mental retardation protein (FMRP) allows the production of certain proteins to go unchecked in the brain. A recent study in mice suggests that bringing excessive translation into balance may provide a key to treating this syndrome (pages 1473–1477).

    • Laura N Smith
    • Christopher W Cowan
    News & Views
    Nature Medicine
    Volume: 19, P: 1370-1371

  • Composites of poly(methyl methacrylate) synthesized by the free-radical polymerization of methyl methacrylate with Aerosol OT (AOT) surfactant added show enhanced resistance to thermal degradation and combustion. Structural analyses over the nm and μm lengthscale show that there are nanoscale domains of hexagonally packed rods and microscale domains of phase-separated surfactant. The self-assembly of AOT occurs concurrently with the combustion resistance. These results show a promising method of introducing structures that result in the desirable properties of thermal stability and combustion resistance into polymer composites.

    • Gregory N Smith
    • James E Hallett
    • Julian Eastoe
    Research
    Polymer Journal
    Volume: 49, P: 711-719