The disparity in the occurrence of rheumatoid arthritis (RA) between men and women is well documented, but the reasons for this difference remain poorly understood. In this article, the authors discuss the factors that might explain the sexual dimorphism of RA, including genetic, endocrine and behavioral differences, and how improving our understanding of the influence of these factors might lead to the development of novel treatments for patients with this disease.
- William J. Kovacs
- Nancy J. Olsen
