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Showing 1–3 of 3 results
Advanced filters: Author: "Neil Aronin" Clear advanced filters

  • To determine long-range linkage between single-nucleotide polymorphisms (SNPs) and the repeat-containing region of a disease-related gene, Liu et al. develop SNP linkage by circularization (SLiC) and lay the groundwork for using allele-specific RNA interference to target insertion or deletion mutations in disease-associated genes.

    • Wanzhao Liu
    • Lori A Kennington
    • Neil Aronin
    Research
    Nature Methods
    Volume: 5, P: 951-953

  • Antisense oligomers targeted to CAG repeats allow allele-specific knockdown of the gene that causes Huntington's disease.

    • Neil Aronin
    News & Views
    Nature Biotechnology
    Volume: 27, P: 451-452

  • The power of small RNAs to shut down specific gene activities has now been brought to bear on an animal model of hepatitis. Mice infused with an siRNA against a cell death receptor recover liver function after experimentally induced injury (pages 347–351).

    • Phillip D. Zamore
    • Neil Aronin
    News & Views
    Nature Medicine
    Volume: 9, P: 266-267