Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–4 of 4 results
Advanced filters: Author: "Neil Johnson" Clear advanced filters

  • Homologous recombination (HR) gene mutations are thought to be synthetic lethal with DNA polymerase theta (Polθ) inhibition. Here, the authors reveal that Polθ addiction is determined by the functional impact of gene mutations on DNA end resection activity.

    • John J. Krais
    • David J. Glass
    • Neil Johnson
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • A growing body of literature deals with the application of theories developed in other disciplines to financial institutions, to which a paper in this issue now adds. As outlined here, however, views differ as to its relevance. See Perspective p.351

    • Neil Johnson
    • Thomas Lux
    News & Views
    Nature
    Volume: 469, P: 302-303

  • The BRCA1-PALB2-BRCA2-RAD51 (BRCA1-P) complex is well known to play a fundamental role in DNA repair, but how the complex recruitment is regulated is still a matter of interest. Here the authors reveal mechanistic insights into RNF168 activity being responsible for PALB2 recruitment, through BARD1-BRCA1 during homologous recombination repair.

    • John J. Krais
    • Yifan Wang
    • Neil Johnson
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • BRCA1 mutations located within the BRCT domain result in proteasomal degradation and sensitivity to PARP inhibitors (PARPi). Here, the authors report genetic rearrangements in the BRCA1 gene that generate a BRCT-less BRCA1 protein isoform, which avoids degradation and leads to PARPi resistance.

    • Yifan Wang
    • Andrea J. Bernhardy
    • Neil Johnson
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12