A team from King's College London presents an overview of the role of complement activation and complement regulatory proteins in kidney injury. They extend their discussion beyond immune-complex-mediated glomerular diseases such as lupus nephritis and membranoproliferative glomerulonephritis to other forms of renal injury in which complement has a role, such as atypical hemolytic uremic syndrome and graft rejection. Their concise and easy to read article includes a discussion of the therapeutic potential of manipulating complement inhibition.
- Katherine M Brown
- Steven H Sacks
- Neil S Sheerin