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Advanced filters: Author: "Neil D. Perkins" Clear advanced filters

  • Nuclear factor-κB (NF-κB) has many functions in cancer, hence the need for drugs that can modulate its activity. In order to achieve this, Neil D. Perkins argues that the complex roles of the individual NF-κB subunits must be considered.

    • Neil D. Perkins
    Reviews
    Nature Reviews Cancer
    Volume: 12, P: 121-132

  • Rather than functioning in isolation, the activities of nuclear factor (NF)-κB and inhibitor of NF-κB kinase (IKK) proteins are integrated with diverse cell-signalling pathways, including the JNK, p53 and nuclear-receptor pathways. This crosstalk determines the consequences of NF-κB and IKK activation and, ultimately, cell fate.

    • Neil D. Perkins
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 8, P: 49-62