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Showing 1–15 of 15 results
Advanced filters: Author: "Nicholas Barker" Clear advanced filters

  • Uterine gland development is essential for successful embryo implantation, decidua formation and placental development. Here the authors demonstrate that neonatal Wnt-dependent Lgr5 expressing stem/progenitor cells at the tips of developing glands are indispensable for uterine gland development.

    • Ryo Seishima
    • Carly Leung
    • Nick Barker
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • The ovary surface epithelium undergoes ovulation-induced tear and remodelling. Barker and colleagues have identified Lgr5-expressing stem cells in the mouse ovary and show that they contribute to ovary organogenesis as well as participate in epithelial repair throughout life.

    • Annie Ng
    • Shawna Tan
    • Nick Barker
    Research
    Nature Cell Biology
    Volume: 16, P: 745-757

  • The mechanisms regulating the progression of benign tumors to malignant carcinomas remain incompletely understood. A new study identifies the transcription factor NR2F2 as a specific regulator of this transition that plays critical roles in the maintenance of the malignant tumor state.

    • Hui Yi Grace Lim
    • Nick Barker
    News & Views
    Nature Cancer
    Volume: 2, P: 1116-1118

  • 2017 has witnessed major advances in gut stem cell and cancer stem cell research, delivering key insights into their regulation, more defined culture methods and novel stem cell markers that collectively drive us ever closer to breakthroughs for regenerative medicine and cancer treatment in the clinic.

    • Nick Barker
    News & Views
    Nature Reviews Gastroenterology & Hepatology
    Volume: 15, P: 78-80

  • Basal cell carcinoma has been shown to originate from activation of hedgehog signalling in interfollicular epidermal progenitor cells. Analyses of the early steps of basal cell carcinoma formation show that this process requires reprogramming of interfolliclular epidermal cells to an embryonic hair follicle progenitor-like fate, with concomitant Wnt pathway activation.

    • David W. M. Tan
    • Nick Barker
    News & Views
    Nature Cell Biology
    Volume: 14, P: 1246-1247

  • At each ovulation cycle, the single-layer epithelia that encapsulate mammalian ovaries undergo rupture and rapid repair. Recent studies have identified stem cell pools that ensure ovarian epithelial homeostasis, thus providing insights into the regulation of stem cell function and the contribution of stem cells to ovarian tumorigenesis.

    • Annie Ng
    • Nick Barker
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 16, P: 625-638

  • Renewal and repair of the intestinal epithelium depend on small populations of intestinal stem cells. Specific markers for these stem cells have recently been discovered. This advance, together with the development of new technologies to track endogenous stem cell activity and to generate new epitheliaex vivo, is shedding light on the mechanisms underlying intestinal stem cell-driven homeostasis and regeneration.

    • Nick Barker
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 15, P: 19-33

  • Barker and colleagues review the history and recent developments of organoid cultures derived from pluripotent stem cells and adult epithelia, and discuss how the technology can be used for basic research as well as translational applications.

    • Aliya Fatehullah
    • Si Hui Tan
    • Nick Barker
    Reviews
    Nature Cell Biology
    Volume: 18, P: 246-254