Both the classical effects of vitamin D on bone and its other, nonclassical, effects, particularly those on the immune system, could be of relevance to rheumatic diseases; indeed vitamin D deficiency has been associated with such conditions in observational studies. The clinical importance of these findings, however, is unclear. This Review appraises the current evidence in this area, particularly in relation to whether vitamin D supplementation should be considered, or not, in approaches to the management of rheumatic disease.
- Bo Abrahamsen
- Nicholas C. Harvey
