How p53 is restrained in arterial maturation during embryonic development is unclear. Here, the authors show that β-catenin C-terminal interactions inhibit CREB binding protein-mediated acetylation and activation of p53 in smooth muscle cells, and that this function is essential for artery formation.
- Dario F. Riascos-Bernal
- Prameladevi Chinnasamy
- Nicholas E. S. Sibinga